Application of the intranasal road of administration for delivery of drugs to the central nervous system

BACKGROUND: The development of effective drug delivery to the central nervous system still remains an important problem in pharmacology despite rapid a large number new treatment strategies recent years. Recently interest intranasal method as route has greatly increased because this administration allows bypass blood-brain barrier. There is not single fundamental study comparing intranasal, and peripheral methods order determine feasibility using for delivering substances brain by far.
 AIM: Aim effect 6-hydroxydopamine (6-OHDA), neurotoxin that does penetrate through barrier various administrations on behavior mice.
 MATERIALS AND METHODS: experiments were performed 40 outbred female mice weighing 2025 g. divided into groups 10 which injected with intraventricular, intraperitoneal, intact 6-OHDA. After 21 days, behavioral responses observed Rotarod test, Verticalization, Open Field, Pole test.
 RESULTS: 1. A significant difference was found between animals after intraventricular 6-OHDA control group when studying open field test. 2. coordination activity test (rotating rod) showed similar decrease retention time rotating drum 3. Only descent 4. increase motor revealed apomorphine verticalization CONCLUSIONS: It concluded pass penetrates administration.